Technical issues in DNA microarray production and utilization: impact on clinical research

The adoption and utilization of genomic technologies in healthcare requires that many issues surrounding the integrity of these assay platforms, as well as their overall impact on human health, be definitive. Many concerns common to DNA microarray production must be addressed to exploit the high-content screening capabilities of this assay platform for both genotyping and gene expression profiling in the clinic. Equally important to the success of genomic technology in healthcare is the development of a supporting information system that offers impact at both the personal and population level, and facilitates the adoption, use and, ultimately, impact of genomic information in therapeutic decision support.