Related Experiment Videos
Diagnostic and prognostic potential of gene microarrays in rheumatoid arthritis
1University of Oklahoma College of Medicine, Department of Pediatrics, Rheumatology Section, Oklahoma City, OK 73104, USA. james-jarvis@ouhsc.edu
Abstract:
Rheumatoid arthritis and juvenile rheumatoid arthritis are histopathologically similar diseases characterized by chronic inflammation of the synovium. The pathogenesis of these diseases is unknown, but the emergence of gene expression profiling provides considerable promise that some of the complex, interconnected immunopathologic events underlying these diseases will soon be better understood. This review will summarize the potential use of gene expression profiling as a diagnostic or prognostic modality, and the potential benefits or limits of such uses. It will conclude with a short discussion of the potential for using gene expression profiling to identify novel targets of therapy in rheumatoid arthritis and related diseases.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
DNA Microarrays
The JAK-STAT Signaling Pathway