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Related Experiment Videos

Sentinel node localization in head and neck tumors.

Karen T Pitman1

  • 1Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS 30216, USA. kpitman@ent.umsmed.edu

Seminars in Nuclear Medicine
|September 10, 2005
PubMed
Summary
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Sentinel lymph node biopsy (SLNB) accurately stages head and neck cancer lymphatics. This minimally invasive technique shows promise for identifying cancer spread, potentially guiding treatment decisions for head and neck squamous cell carcinoma (HNSCC).

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Sentinel lymph node biopsy (SLNB) is established for staging cutaneous melanoma.
  • SLNB feasibility is demonstrated for staging cervical lymphatics in head and neck squamous cell carcinoma (HNSCC).

Purpose of the Study:

  • To investigate the accuracy of SLNB in staging HNSCC.
  • To compare SLNB results with standard elective neck dissection in HNSCC patients.

Main Methods:

  • A multicenter study sponsored by the American College of Surgeons Oncology Group is evaluating SLNB accuracy.
  • Research indicates multiple sentinel lymph nodes (SLNs) and variable drainage patterns in head and neck mucosal sites.

Main Results:

  • Ongoing multicenter study comparing SLNB to elective neck dissection for HNSCC accuracy.

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  • Evidence suggests individualized lymphatic drainage patterns in head and neck mucosal sites.

    • Conclusions:

    • SLNB is a feasible and accurate method for staging HNSCC.
    • Lymphoscintigraphy may help delineate lymphatic basins for treatment in HNSCC, especially with prior surgery or irradiation.