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Related Experiment Videos

Lung development is not necessary for diaphragm development in mice.

Marc S Arkovitz1, Brian A Hyatt, John M Shannon

  • 1Division of Pediatric Surgery, Children's Hospital of New York, New York, NY 10032-3784, USA. ma2161@columbia.edu

Journal of Pediatric Surgery
|September 10, 2005
PubMed
Summary

In mice, normal diaphragm development occurs independently of lung development, even in cases of severe lung hypoplasia caused by fibroblast growth factor 10 (FGF10) gene deletion.

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Developmental biology·2018

Area of Science:

  • Developmental biology
  • Genetics
  • Medical research

Background:

  • Congenital diaphragmatic hernia (CDH) is a birth defect affecting 1 in 2000 live births.
  • The exact causes of CDH and associated diaphragmatic defects remain unknown.
  • Lung hypoplasia, a condition of incomplete lung development, is often observed in CDH.

Purpose of the Study:

  • To investigate the relationship between lung development and diaphragmatic development.
  • To examine diaphragmatic development in mice lacking fibroblast growth factor 10 (FGF10), which exhibit severe lung hypoplasia.

Main Methods:

  • Analysis of diaphragms from FGF10 null mice at two embryonic stages.
  • Comparison of diaphragmatic morphology between FGF10 null mice and their heterozygous and wild-type littermates.

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Main Results:

  • FGF10 null mice showed phenotypically normal diaphragms.
  • Diaphragmatic development was comparable between FGF10 null mice and wild-type littermates at both studied time-points.

Conclusions:

  • Diaphragm development in mice appears to proceed normally, irrespective of lung development.
  • These findings suggest that lung development is not a prerequisite for normal diaphragm formation in this model.