Related Experiment Video

Updated: Aug 16, 2026

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
09:12

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

Fcgamma-receptor IIA genotype and invasive pneumococcal infection

Leen Moens1, Erna Van Hoeyveld, Jan Verhaegen

  • 1Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B-3000 Leuven, Belgium.

Clinical Immunology (Orlando, Fla.)
|September 10, 2005
PubMed

Insights

This study investigated the link between Fcgamma-RIIA genotype and invasive pneumococcal disease. Researchers found no association between Fcgamma-RIIA genetic variations and the disease in Caucasian patients.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • Streptococcus pneumoniae causes severe infections like pneumonia and meningitis, particularly in vulnerable populations.
  • The Fcgamma-RIIA receptor is critical for clearing IgG2-opsonized bacteria through phagocytosis.
  • Fcgamma-RIIA receptor genetic variations may influence susceptibility to pneumococcal infections.

Purpose of the Study:

  • To investigate the association between Fcgamma-RIIA (Fc gamma-IIA receptor) genotypes and invasive pneumococcal disease (IPD).

Main Methods:

  • Prospective study design.
  • Genotyping of the Fcgamma-RIIA receptor in 55 Caucasian patients with invasive pneumococcal disease.
  • Comparison with 100 Caucasian control individuals.

Main Results:

  • No statistically significant association was found between Fcgamma-RIIA genotypes and invasive pneumococcal disease.
  • This finding contrasts with some previous reports suggesting a potential link.

Conclusions:

  • The Fcgamma-RIIA genotype does not appear to be a significant risk factor for invasive pneumococcal disease in the studied Caucasian population.
  • Further research may be needed to explore other genetic or environmental factors influencing pneumococcal disease susceptibility.

More Related Videos

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...