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Cardiopulmonary baroreflex is reset during dynamic exercise.

Shigehiko Ogoh1, R Matthew Brothers, Quinton Barnes

  • 1Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107, USA. sogoh@hsc.unt.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 10, 2005
PubMed
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During exercise, the cardiopulmonary baroreflex adjusts to increased cardiac filling pressures. This study found the baroreflex operating point resets during exercise, accommodating higher cardiac filling volumes and pressures.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Autonomic Regulation

Background:

  • The cardiopulmonary baroreflex regulates blood pressure and fluid balance.
  • Exercise alters cardiac filling pressures and volumes.
  • Understanding baroreflex adaptation during exercise is crucial for cardiovascular health.

Purpose of the Study:

  • To test if the cardiopulmonary baroreflex operating point shifts to higher cardiac filling pressures during exercise.
  • To investigate the role of increased cardiac filling volumes in baroreflex resetting during physical activity.

Main Methods:

  • Eight healthy men underwent lower body negative pressure (LBNP) and albumin infusions at rest and during cycling exercise.
  • Central venous pressure (CVP), heart rate, arterial blood pressure, forearm blood flow, and cardiac output were continuously monitored.

Related Experiment Videos

  • Vascular conductance was calculated to assess autonomic responses to altered filling pressures.

    • Main Results:

    • Exercise significantly increased forearm and total systemic vascular conductance.
    • Responses of vascular conductance to LBNP and albumin infusion did not differ significantly between rest and exercise.
    • These findings suggest baroreflex resetting occurs during exercise.

    Conclusions:

    • The cardiopulmonary baroreflex is reset during exercise to a higher operating point.
    • This resetting accommodates exercise-induced increases in cardiac filling volume and pressure.
    • The autonomic regulation of vascular tone adapts to the physiological demands of exercise.