Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Excellent cognitive performance despite massive cerebral white matter changes.

Thomas Duning1, Harald Kugel, Stefan Knecht

  • 1Department of Neurology, University of Münster, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany. duningt@uni-muenster.de

Neuroradiology
|September 10, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resolving a three-decade misassignment in hydroxylated C60 chemistry.

Communications chemistry·2026
Same author

Is there a cognitive measure of neurodegeneration for amyloid-Aβ-ratio probable Alzheimer's disease patients?

Journal of Alzheimer's disease : JAD·2026
Same author

Cognitive tests distinguish biomarker-verified early Alzheimer's disease from other patients.

BMC neurology·2026
Same author

Approximate quantum circuit compilation for proton-transfer kinetics on quantum processors.

Physical chemistry chemical physics : PCCP·2026
Same author

The Paper-Toss Test: enhancing bedside recognition of corticobasal syndrome.

Frontiers in neurology·2025
Same author

MMW Fortschritte der Medizin·2025
Same journal

Enhanced detection of subtle cortical abnormalities in focal epilepsy using 7 T MRI surface-based models and graph neural networks.

Neuroradiology·2026
Same journal

Anterior cerebral artery variants and their influence on endovascular outcomes: a propensity score matched analysis from the CRETA registry.

Neuroradiology·2026
Same journal

Super-resolution deep learning reconstruction for brain fluid-attenuated inversion recovery: image quality and white matter hyperintensity volume analysis.

Neuroradiology·2026
Same journal

Deep learning for contrast-enhanced MRI in pediatric brain imaging.

Neuroradiology·2026
Same journal

Beyond complex architectures: a streamlined CNN pipeline for robust Alzheimer's disease classification from brain MRI.

Neuroradiology·2026
Same journal

Thalamic, Hippocampal, and Amygdalar subregional volumetric alterations in neonates with isolated aEEG abnormalities.

Neuroradiology·2026
See all related articles

Extensive white matter changes on MRI scans in older adults do not always indicate cognitive decline. This case highlights the importance of comprehensive assessment beyond imaging findings.

Area of Science:

  • Neurology
  • Geriatrics
  • Radiology

Background:

  • Cerebral white matter changes are common in elderly individuals undergoing magnetic resonance imaging (MRI).
  • These changes are frequently associated with diminished cognitive function in the aging population.

Observation:

  • A case study involving an elderly patient with significant white matter abnormalities detected via MRI.
  • The patient exhibited remarkably preserved cognitive abilities despite the extensive imaging findings.

Findings:

  • The observed massive white matter changes did not correlate with a decline in cognitive performance.
  • This presents a discrepancy between neuroimaging results and actual cognitive status.

Implications:

Related Experiment Videos

  • Challenges the automatic assumption linking white matter changes to cognitive impairment in the elderly.
  • Emphasizes the need for a holistic approach to cognitive assessment, integrating imaging data with clinical evaluation.
  • Suggests further research into the dissociation between structural brain changes and functional cognition in aging.