Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Common variable immunodeficiency with increased surface IgM-positive double-bearing B cells.

F Motoyoshi1, S Mori, N Kondo

  • 1Department of Pediatrics, Gifu University School of Medicine, Japan.

Scandinavian Journal of Immunology
|July 1, 1992
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EAD and DAD mechanisms analyzed by developing a new human ventricular cell model.

Progress in biophysics and molecular biology·2014
Same author

Characterization of disease resistance gene-like sequences in near-isogenic lines of tomato.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2014
Same author

The mechanism of infection of plant protoplasts by viruses.

Planta·2014
Same author

Effect of poly-L-ornithine on isolated tobacco mesophyll protoplasts: Evidence against stimulated pinocytosis.

Planta·2014
Same author

Structural changes accompanying infection of tobacco protoplasts with two spherical viruses.

Planta·2014
Same author

Structural and autoradiographic observations of the infection of tobacco protoplasts with pea enation mosaic virus.

Planta·2014

Common Variable Immunodeficiency (CVI) patients with normal IgM may have defective B cell switching. This study reveals impaired IgG and IgA production due to a defect in immunoglobulin class switching.

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Common Variable Immunodeficiency (CVI) is a primary immunodeficiency characterized by hypogammaglobulinemia.
  • While typically associated with low IgM, some CVI cases present with normal IgM levels, posing diagnostic challenges.

Observation:

  • The patient exhibited low IgG and IgA but normal IgM levels, with intact T-cell function.
  • Increased B cells expressing surface IgM and IgD, or IgM and IgG, or IgM and IgA were noted.
  • B cells failed to induce IgG and IgA upon stimulation with SAC/rIL-2 or PWM/rIL-4/rIL-6, despite proliferation.

Findings:

  • Mu mRNA expression was normal, but gamma and alpha mRNA transcription was significantly reduced.
  • Stimulation with rIL-4 and rIL-6 did not enhance gamma or alpha mRNA expression.

Related Experiment Videos

  • These findings indicate a defect in B cell immunoglobulin class switching from IgM to IgG or IgA.

    • Implications:

    • This case highlights a specific B cell defect in immunoglobulin class switching as a cause of CVI, even with normal IgM.
    • Understanding this defect is crucial for accurate diagnosis and potential therapeutic strategies in CVI patients.
    • Further research into the molecular mechanisms of this switching defect could offer new insights into B cell development and immune regulation.