The implications of the failure to generate autoantibody-producing hybridomas from rat erythrocyte-immunized mice

Injection of mice with rat erythrocytes (RRBC) has long been thought to provide an experimental model in which suppressor T cells (Ts) control autoimmunity. The basis of this is that whilst mice immunized with RRBC produce an antibody response, of which a proportion cross-reacts with autologous red cells, the RRBC-immunized recipients of RRBC-primed spleen cells make no, or little, autoantibody, and secondly because the transfer of this autoantibody-specific suppression can be abrogated by T-cell depletion of transferred spleen cells. Here an alternative explanation of these phenomena is described.