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Clonorchiasis: an update.

H-J Rim1

  • 1Department of Paraitology, College of Medicine, Korea university, Seoul 136-705, Korea. hjrim@kora.ac.kr

Journal of Helminthology
|September 13, 2005
PubMed
Summary

Clonorchis sinensis, a liver fluke, causes clonorchiasis through raw fish consumption. This review covers its epidemiology, pathology, diagnosis, and control, highlighting praziquantel as the treatment of choice.

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Area of Science:

  • Parasitology
  • Infectious Diseases
  • Public Health

Background:

  • Clonorchis sinensis (Chinese liver fluke) is a significant human parasite prevalent in East Asia and among Asian immigrants globally.
  • Infection occurs via ingestion of raw fish containing metacercariae, with snails and freshwater fish as intermediate hosts.
  • Decades of research have advanced understanding of its morphology, biology, pathogenesis, epidemiology, clinical features, and treatment.

Purpose of the Study:

  • To review current epidemiological, pathological, and clinical aspects of clonorchiasis.
  • To discuss diagnostic methods and effective control strategies for Clonorchis sinensis infections.
  • To present experimental findings on the link between clonorchiasis and cholangiocarcinoma.

Main Methods:

  • Review of existing literature on Clonorchis sinensis epidemiology, pathology, and clinical manifestations.
  • Analysis of diagnostic techniques including imaging (cholangiography, sonography, CT, MRI).
  • Evaluation of praziquantel efficacy and recommended treatment regimens.

Main Results:

  • Clonorchiasis is characterized by biliary calculus formation, potentially leading to suppurative cholangitis, cholecystitis, cholangiohepatitis, and cholangiocarcinoma.
  • Praziquantel is the primary drug for clonorchiasis, with a specific effective dosage regimen.
  • Current research includes immunology, molecular biology, and control measures in endemic regions.

Conclusions:

  • Clonorchiasis poses significant health risks, including cholangiocarcinoma, necessitating effective control measures.
  • Accurate diagnosis relies on clinical presentation and advanced imaging techniques.
  • Integrated control strategies and praziquantel treatment are crucial for managing clonorchiasis.

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