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Inherited predisposition to lung cancer
1Department of Medicine, University of Maryland, Baltimore 21201.
Occupational Medicine (Philadelphia, Pa.)
|April 1, 1992
Summary
Inherited factors significantly impact lung cancer risk. Understanding these genetic predispositions and cellular processes can help estimate cancer risk in individuals exposed to environmental carcinogens.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- Lung cancer incidence is influenced by inherited predispositions.
- Neoplastic transformation and tumor progression involve complex biologic events.
- Host defense mechanisms play a role in limiting tumor development.
Purpose of the Study:
- To summarize evidence on inherited predisposition in lung cancer.
- To review cellular mechanisms of carcinogenesis and tumor progression.
- To explore the application of carcinogenesis knowledge in risk assessment for environmental exposures.
Main Methods:
- Review of epidemiologic data.
- Analysis of animal model studies.
- Examination of cell biologic events and host mechanisms.
Main Results:
- Epidemiologic and animal studies confirm a role for inherited predisposition in lung cancer.
- Cellular events driving neoplastic transformation and tumor progression are identified.
- Host mechanisms capable of inhibiting tumor genesis and progression are described.
Conclusions:
- Inherited factors are crucial in lung cancer development.
- Understanding carcinogenesis mechanisms aids in assessing individual risk from environmental carcinogens.
- This knowledge can inform personalized lung cancer risk evaluation.