Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IMRT for breast. a planning study.

A Fogliata1, G Nicolini, M Alber

  • 1Oncology Institute of Southern Switzerland, Medical Physics, Bellinzona, Switzerland.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|September 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the interface between linguistics, computer science and psychiatry: analyzing textual key-factors affecting BERT-based classification of schizophrenia in social media texts.

Frontiers in artificial intelligence·2026
Same author

Clinical standards for antimicrobial stewardship in TB care.

IJTLD open·2025
Same author

Comparing end-user diagnostic outputs from a commercial tNGS pipeline for <i>Mycobacterium tuberculosis</i> drug resistance detection.

IJTLD open·2025
Same author

New insights into structural, optical, electrical and thermoelectric behavior of Na<sub>0.5</sub>Bi<sub>0.5</sub>TiO<sub>3</sub> single crystals.

Scientific reports·2025
Same author

Novel Bragg peak characterization method using proton flux measurements on plastic scintillators.

Physics in medicine and biology·2024
Same author

Recommendations for the implementation of a national lung cancer screening program in Portugal-A consensus statement.

Pulmonology·2024
Same journal

Definitive IMRT alone with reduced prophylactic nodal irradiation for Early-Stage Oropharyngeal Cancer: JCOG1208.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Associations between body composition and radiotherapy-related side-effects and health-related quality of life in patients with prostate or lung cancer: sub-analysis of the REQUITE trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

ESTRO recommendations for the use, planning and delivery of reirradiation in locally recurrent rectal cancer - Endorsed by ASTRO.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Early ADC changes in risk-model-defined brain regions precede contrast-enhancing lesions after proton therapy for low-grade glioma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Any impact of pre-operative radiotherapy on renal function in retroperitoneal soft tissue sarcomas? A secondary ancillary analysis of the EORTC 62092 STRASS 1 trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Tumor volume reduction during adaptive radiotherapy is a strong prognostic factor for oropharyngeal cancer: A retrospective multicenter study?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
See all related articles

Ten intensity modulated radiation therapy (IMRT) planning systems were evaluated for breast cancer treatments including the internal mammary chain. Eclipse and Pinnacle showed superior target coverage, while minimizing dose to organs at risk.

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Cancer Treatment

Background:

  • Intensity modulated radiation therapy (IMRT) is a complex technique for delivering precise radiation doses.
  • Accurate treatment planning is crucial for optimizing radiation delivery in breast cancer, particularly when the internal mammary chain is involved.

Purpose of the Study:

  • To compare the performance of ten different treatment planning systems for IMRT in breast cancer.
  • To assess the ability of these systems to achieve target coverage and spare organs at risk.

Main Methods:

  • A standardized dataset from five patients was used to create IMRT plans on ten different systems.
  • Plans were evaluated based on dose distributions and dose-volume histograms to ensure consistent planning aims and geometry.

Related Experiment Videos

Main Results:

  • Significant variations in target coverage and organ-at-risk sparing were observed across the ten systems.
  • Eclipse and Pinnacle demonstrated the highest target coverage (91%), while Hyperion had the lowest overdose (3.3%).
  • Dose to the ipsilateral lung, contralateral breast, and heart varied considerably, with Eclipse showing favorable sparing for heart and lung.

Conclusions:

  • The choice of treatment planning system significantly impacts IMRT plan quality for breast cancer with internal mammary chain irradiation.
  • Optimized treatment geometry can minimize contralateral breast irradiation and organ-at-risk doses while maintaining target coverage.
  • Further research is needed to establish standardized performance benchmarks for IMRT planning systems in this clinical scenario.