Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ca2+ and synaptic plasticity.

Michele Cavazzini1, Tim Bliss, Nigel Emptage

  • 1Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.

Cell Calcium
|September 13, 2005
PubMed
Summary

Synaptic plasticity relies on calcium ions (Ca2+). Fluorescent imaging reveals complex neuronal Ca2+ signaling patterns, translating neuronal activity into a dynamic Ca2+ code.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pursuing Synaptic Plasticity From Cortex to LTP in the Hippocampus.

Hippocampus·2024
Same author

Biomarkers of Clinician Burnout.

Journal of general internal medicine·2021
Same author

Optical Quantal Analysis Using Ca<sup>2+</sup> Indicators: A Robust Method for Assessing Transmitter Release Probability at Excitatory Synapses by Imaging Single Glutamate Release Events.

Frontiers in synaptic neuroscience·2019
Same author

Fast volume-scanning light sheet microscopy reveals transient neuronal events.

Biomedical optics express·2018
Same author

Glutamate is required for depression but not potentiation of long-term presynaptic function.

eLife·2017
Same author

A compact light-sheet microscope for the study of the mammalian central nervous system.

Scientific reports·2016

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Biochemistry

Background:

  • Synaptic plasticity, crucial for learning and memory, is a Ca2+-dependent process.
  • Neuronal Ca2+ signaling is compartmentalized, with diverse patterns observed across different cellular regions.
  • Ca2+ signals originate from both influx and intracellular stores, reflecting neuronal activity.

Purpose of the Study:

  • To investigate the dynamic Ca2+ signaling patterns within neurons.
  • To understand how these Ca2+ signals are interpreted by sensor proteins.
  • To elucidate the mechanisms of compartment-specific synaptic plasticity induction.

Main Methods:

  • Fluorescent imaging techniques were employed to monitor intracellular Ca2+ ([Ca2+]i) changes.
  • Analysis of Ca2+ signaling patterns across various neuronal compartments.
  • Investigating the link between neuronal activity and Ca2+ dynamics.

Main Results:

  • Fluorescent imaging demonstrated diverse intracellular Ca2+ signaling patterns in neurons.
  • Neuronal input/output is translated into a dynamic Ca2+ code.
  • Ca2+ signals are generated via voltage/ligand-gated influx and intracellular release.

Conclusions:

  • Understanding the interpretation of the Ca2+ code by sensor proteins is critical.
  • Further research is needed to link Ca2+ dynamics to compartment-specific plasticity.
  • Elucidating these mechanisms is key to understanding neuronal function.

Related Experiment Videos