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Updated: Aug 16, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Functional imaging of pain and analgesia--a valid diagnostic tool?

David Borsook1, Lino Becerra

  • 1Brain Imaging Centre, Department of Psychiatry, P.A.I.N. Group, McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA 02478, USA.

Pain
|September 13, 2005
PubMed
Abstract

No abstract available in PubMed .

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...