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Antibiotic resistance trends in paediatric uropathogens

Romolo J Gaspari1, Eric Dickson, James Karlowsky

  • 1Department of Emergency Medicine, University of Massachusetts School of Medicine, University of Massachusetts, Worcester, 01655, USA. GaspariR@ummbc.org

International Journal of Antimicrobial Agents
|September 13, 2005
PubMed

Insights

Pediatric urinary tract infections show high resistance to common antibiotics like ampicillin. This study analyzed antimicrobial susceptibility in young patients, revealing concerning trends in antibiotic resistance.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial resistance
  • Clinical microbiology

Background:

  • Urinary tract infections (UTIs) are common in children.
  • Antibiotic resistance in pediatric uropathogens is a growing concern.
  • Understanding susceptibility patterns is crucial for effective UTI treatment in children.

Purpose of the Study:

  • To determine antimicrobial susceptibility patterns of common pediatric uropathogens.
  • To assess resistance rates to six frequently used antibiotics for UTIs in children.
  • To stratify resistance data by pediatric age groups and sex.

Main Methods:

  • Analysis of bacterial isolates from urine cultures of pediatric outpatients (April 2002-May 2004).
  • Inclusion of the six most common uropathogens.
  • Stratification of results by pediatric age group and sex.

Main Results:

  • High overall resistance rates were observed: ampicillin (44.3-44.6%), sulfamethoxazole/trimethoprim (24.5-36.7%).
  • Lower but notable resistance to amoxicillin/clavulanic acid (12.4-27.5%) and cefazolin (10.9-27.1%).
  • Ciprofloxacin (0.9-2.4%) and nitrofurantoin (4.4-11.0%) showed lower resistance rates.

Conclusions:

  • Pediatric uropathogens exhibit high resistance to several commonly prescribed antibiotics for UTIs.
  • Significant sex-based differences in resistance rates were noted for most antibiotics.
  • These findings highlight the need for regular surveillance and updated treatment guidelines for pediatric UTIs.

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