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Biocidal activity of some Mannich base cationic derivatives
Nabel A Negm1, Salwa M I Morsy, Medhat M Said
1Egyptian Petroleum Research Institute, Applied Surfactant Laboratory, Petrochemicals Department, Cairo, Egypt. nabelnegm@hotmail.com
Bioorganic & Medicinal Chemistry
|September 13, 2005
Summary
Novel cationic surfactants derived from Mannich bases exhibit significant biocidal activity. These surfactants effectively inhibit Gram-positive and Gram-negative bacteria, as well as yeast and fungi.
Area of Science:
- Organic Chemistry
- Surface Chemistry
- Antimicrobial Agents
Background:
- Mannich bases are versatile intermediates in organic synthesis.
- Cationic surfactants possess diverse applications, including antimicrobial properties.
- 8-hydroxyquinoline derivatives are known for their biological activities.
Purpose of the Study:
- To synthesize and characterize novel cationic surfactants using Mannich bases.
- To evaluate the surface activities and adsorption properties of the synthesized surfactants.
- To assess the antimicrobial efficacy of these novel compounds against various pathogens.
Main Methods:
- Synthesis of cationic surfactants via Mannich reaction involving piperidine/morpholine, paraformaldehyde, and 8-hydroxyquinoline.
- Structural elucidation using elemental analysis, FTIR, and 1H NMR spectroscopy.
- Measurement of surface tension, critical micelle concentration (CMC), interfacial tension, emulsification, and foaming power.
- Determination of biocidal activity against Gram-positive bacteria, Gram-negative bacteria, fungi, and yeast.
Main Results:
- Successful synthesis and structural confirmation of a novel series of cationic surfactants.
- Comprehensive characterization of surface activities, including CMC, surface excess, and minimum surface area.
- Demonstrated significant inhibition against Gram-positive bacteria, Gram-negative bacteria, and yeast.
- Exhibited excellent fungicidal activity against tested fungal strains.
Conclusions:
- The synthesized cationic surfactants possess notable surface activity and adsorption characteristics.
- These novel compounds display promising broad-spectrum antimicrobial properties.
- The study highlights the potential of Mannich base-derived surfactants as effective biocidal agents.