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Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized

Kenneth F Adams1, Paul D Lampe, Katherine M Newton

  • 1Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

The American Journal of Clinical Nutrition
|September 13, 2005
PubMed
Summary
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Soy isoflavones did not reduce colorectal cell proliferation in polyp patients. Instead, supplementation with soy protein containing isoflavones increased cell proliferation in the sigmoid colon.

Area of Science:

  • Nutrition Science
  • Gastroenterology
  • Cancer Research

Background:

  • Soy isoflavones possess biological properties suggesting potential protection against colorectal cancer.
  • Colorectal epithelial cell proliferation is a key biomarker for colorectal neoplasia.

Purpose of the Study:

  • To investigate the effect of soy protein and isoflavone supplementation on colorectal epithelial cell proliferation.
  • To test the hypothesis that isoflavone intake reduces cell proliferation in individuals with a history of colorectal polyps.

Main Methods:

  • A 12-month randomized controlled trial involving 150 participants aged 50-80 with recent adenomatous polyps.
  • Participants received either soy protein with isoflavones (+ISO) or soy protein without isoflavones (-ISO).
  • Colorectal biopsies were analyzed for cell proliferation using Ki-67 immunohistostaining.

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Main Results:

  • Supplementation with soy protein containing isoflavones did not decrease, but rather increased, cell proliferation in the sigmoid colon.
  • Increased cell proliferation in the cecum and sigmoid colon correlated with higher serum genistein concentrations.
  • No significant changes in proliferation distribution or crypt height were observed across treatment groups.

Conclusions:

  • Soy protein and isoflavone supplementation does not inhibit colorectal epithelial cell proliferation.
  • The intervention showed an increase in cell proliferation measures in the sigmoid colon, contrary to the initial hypothesis.
  • These findings suggest that soy isoflavones may not be beneficial for reducing colorectal cell proliferation in this population.