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Related Experiment Video

Updated: Feb 9, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Toxic neuropathy.

Thirugnanam Umapathi¹, Vinay Chaudhry

¹Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore. Umapathi_Thirugnanam@nni.com.sg

Current Opinion in Neurology

|September 13, 2005

Summary

This summary is machine-generated.

Research explores toxic neuropathy treatments and agents causing peripheral neuropathy. Promising therapies include gene therapy and growth factors, while statins and thalidomide present risks.

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Last Updated: Feb 9, 2026

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Published on: January 3, 2011

Area of Science:

Neuroscience
Toxicology
Pharmacology

Background:

Peripheral neuropathy is a significant clinical concern.
Understanding neurotoxic agents is crucial for patient safety and treatment development.

Purpose of the Study:

To review recent research on toxic neuropathy.
To examine potential therapeutic developments for neurotoxicity.
To summarize agents reported to cause peripheral neuropathy.

Main Methods:

Literature review of recent studies on toxic neuropathy and therapeutic agents.
Analysis of reported cases and animal models of drug-induced peripheral neuropathy.

Main Results:

Gene therapy and neurotrophic factors show promise in animal models.
Established agents like vitamin E, tacrolimus, and erythropoietin offer neuroprotection.
Several drugs, including statins, thalidomide, bortezomib, oxaliplatin, epothilone, and leflunomide, are associated with peripheral neuropathy, with varying incidences and risk factors.

Conclusions:

The study of toxic neuropathy deepens understanding of neurotoxicity mechanisms.
Research in this field is advancing the neurobiology of peripheral neuropathy.
This knowledge is expected to guide the development of novel therapeutics.