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Related Experiment Videos

Pressure-flow relations in canine collateral-dependent cerebrum.

M G Muhonen1, P D Sawin, C M Loftus

  • 1Division of Neurosurgery, University of Iowa College of Medicine, Iowa City 52242.

Stroke
|July 1, 1992
PubMed
Summary

Cerebral blood flow autoregulation differs in collateral-dependent brain tissue. Small vessel resistance fails to decrease during hypotension, leading to severe hypoperfusion in these areas.

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Area of Science:

  • Neurology
  • Cerebrovascular Physiology

Background:

  • Cerebral pressure-flow relations are established in normal brain.
  • These relations are not well-understood in brain tissue reliant on collateral circulation.

Purpose of the Study:

  • To investigate the relationship between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pressure.
  • To compare these relationships in both collateral-dependent and normal brain tissue.

Main Methods:

  • Anesthetized dogs underwent middle cerebral artery branch cannulation.
  • Collateral-dependent tissues were identified using shadow flow technique.
  • Cerebral blood flow and pressure were measured during carotid occlusion and induced hypotension (50 and 25 mm Hg).

Main Results:

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  • In collateral-dependent zones, blood flow dropped significantly (87 to 6 ml/100 g/min) at 25 mm Hg aortic pressure.
  • Middle cerebral artery branch pressure also decreased substantially (49 to 2 mm Hg).
  • Small-vessel resistance in collateral-dependent areas decreased post-carotid occlusion but did not adapt further during hypotension, unlike in normal brain.

Conclusions:

  • The study establishes pressure-flow dynamics in normal and collateral-dependent cerebrum.
  • Concurrent middle cerebral and carotid artery occlusion induces autoregulatory vasodilation.
  • Failure of resistance to decrease during hypotension in collateral-dependent tissue results in profound hypoperfusion.