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Primary amenorrhea. Varied etiology.

Sangeeta M Bhat1, Ilham M Hamdi

  • 1Department of Obstetrics and Gynecology, Nizwa Hospital, PO Box 1222, Postal Code 611, Al-Dakhliya Region, Sultanate of Oman. sangeeta_1965@hotmail.com

Saudi Medical Journal
|September 13, 2005
PubMed
Summary

Primary amenorrhea diagnosis involves evaluating delayed puberty and absence of menses. This study identified three distinct causes through chromosomal, hormonal, and surgical analyses in three cases.

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Area of Science:

  • Reproductive Endocrinology
  • Pediatric Gynecology

Background:

  • Primary amenorrhea, the absence of menstruation by age 14 with no secondary sexual characteristics or within 4 years of pubertal onset, requires thorough investigation.
  • Delayed puberty and absent menses are key indicators for initiating diagnostic workup.

Purpose of the Study:

  • To investigate and identify the varied etiologies of primary amenorrhea in three distinct cases.
  • To demonstrate the diagnostic utility of a comprehensive approach including genetic, hormonal, and surgical evaluations.

Main Methods:

  • Diagnostic workup involved chromosomal analysis for genetic assessment.
  • Hormonal assays were performed to evaluate endocrine function.
  • Diagnostic laparoscopy and histopathological examination of biopsied samples provided direct tissue assessment.

Main Results:

  • Three unique etiological factors contributing to primary amenorrhea were identified across the three cases.
  • The integrated diagnostic approach successfully established specific diagnoses for each patient.

Conclusions:

  • A multidisciplinary diagnostic strategy is crucial for elucidating the causes of primary amenorrhea.
  • Accurate diagnosis through chromosomal, hormonal, and surgical methods enables targeted management of primary amenorrhea.

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