Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serotonin receptors and cognitive behaviour--an update.

M C Buhot1, G Malleret, L Segu

  • 1Centre National de la Recherche Scientifique, UMR 5807, Université de Bordeaux I, Avenue des Facultés, 33405 Talence Cedex, France. buhot@neurocog.u-bordeaux.fr

Idrugs : the Investigational Drugs Journal
|September 13, 2005
PubMed
Summary

The serotonergic system, involving specific serotonin receptors, impacts cognitive functions like memory. New research tools will further clarify its role in cognition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-activation of VEGF and NMDA receptors promotes synaptic targeting of AMPA receptors.

Molecular psychiatry·2016
Same author

Guidance for Risk Sharing Agreements / Pay Per: Results SCHEMES FOR PHARMACEUTICALS IN CATALONIA (SPAIN).

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid.

Journal of neuroinflammation·2016
Same author

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior.

Molecular psychiatry·2016
Same author

Nest-box exploration and choice in male and female mice tested under individual and social conditions.

Behavioural processes·2014
Same author

Extinction of spatial memory alters CREB phosphorylation in hippocampal CA1.

Hippocampus·2010

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • The serotonergic system influences behaviors requiring high cognitive demand and memory.
  • Serotonin receptor subtypes are key targets for modulating cognitive performance.

Purpose of the Study:

  • To elucidate the role of specific serotonin receptor subtypes in cognitive functions.
  • To explore the impact of receptor agonists and antagonists on cognitive performance.

Main Methods:

  • Administration of 5-HT(2A/2C) and 5-HT4 receptor agonists.
  • Administration of 5-HT1A, 5-HT3, and 5-HT1B receptor antagonists.
  • Localization of receptor subtypes on cognitive pathways, including the hippocampus and frontal cortex.

Main Results:

  • Evidence suggests involvement of specific serotonin receptors in cognitive demand and memory.

Related Experiment Videos

  • Agonists and antagonists targeting these receptors show effects on cognitive performance.

    • Conclusions:

    • The serotonergic system, through specific receptor subtypes, plays a significant role in cognition.
    • Advanced tools like specific ligands and gene knock-out mice will enhance understanding of these mechanisms.