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Imaging the Human Immunological Synapse
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Imaging the Human Immunological Synapse

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Nuvance (Immunex)

R W Lange1

  • 1Department of Environmental Occupational Health, University of Pittsburgh, RIDC Park, Pittsburgh, PA 15238, USA. lange@pop.pitt.edu

Idrugs : the Investigational Drugs Journal
|September 13, 2005
PubMed

Immunex is carrying out worldwide phase II trials on a genetically-engineered soluble interleukin-4 receptor (IL-4R, Nuvance), administered as a nebulized liquid, for the potential treatment of allergic asthma. IL-4R may also be of use in the treatment of organ transplant rejection, graft versus host disease, allergy and infectious disease.

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Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
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Cross-reactivity

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