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Risk factors for concomitant peripheral arterial occlusive disease in patients with coronary artery disease: is there

N Papanas1, D Tziakas, E Maltezos

  • 1Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece. papanasnikos@yahoo.gr

Acta Clinica Belgica
|September 15, 2005
PubMed

Insights

Diabetic patients with coronary artery disease (CAD) and peripheral arterial occlusive disease (PAOD) have longer diabetes duration and higher insulin use. Non-diabetic CAD patients with PAOD are older.

Area of Science:

  • Cardiovascular Medicine
  • Diabetology
  • Vascular Surgery

Background:

  • Coronary artery disease (CAD) and peripheral arterial occlusive disease (PAOD) are significant causes of morbidity and mortality.
  • Diabetes mellitus is a major risk factor for both CAD and PAOD.
  • Understanding the interplay of cardiovascular risk factors in diabetic versus non-diabetic patients with concomitant CAD and PAOD is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate and compare cardiovascular risk factors associated with concomitant peripheral arterial occlusive disease (PAOD) in diabetic versus non-diabetic patients who have coronary artery disease (CAD).

Main Methods:

  • A study included 302 patients with angiographically documented CAD, divided into 116 diabetic (Group A) and 186 non-diabetic (Group B) patients.
  • PAOD was diagnosed using Doppler ultrasonography.
  • Cardiovascular risk factors assessed included age, history of myocardial infarction, smoking, Body-Mass Index, Waist-Hip-Ratio, hypertension, and serum lipids.

Main Results:

  • PAOD was diagnosed in 42.4% of diabetic patients and 10.8% of non-diabetic patients.
  • In diabetic patients (Group A), PAOD was associated with longer diabetes duration, higher insulin treatment frequency, higher triglycerides, and lower HDL-cholesterol.
  • In non-diabetic patients (Group B), PAOD was associated with older age and higher LDL-cholesterol levels. Multiple regression analysis confirmed diabetes duration and insulin treatment in Group A, and age in Group B, as significant predictors.

Conclusions:

  • Concomitant PAOD in non-diabetic patients with CAD is significantly associated with older age.
  • In diabetic patients with CAD, concomitant PAOD is significantly linked to longer diabetes duration and a higher frequency of insulin treatment.
  • These findings highlight distinct risk factor profiles for PAOD in diabetic versus non-diabetic patients with CAD, informing targeted prevention and treatment strategies.
Abstract

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