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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Ushikulides A and B, immunosuppressants produced by a strain of Streptomyces sp
Kosaku Takahashi1, Teruhiko Yoshihara, Kazuhiko Kurosawa
1Graduate School of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan. kosaku@chem.agr.hokudai.ac.jp
Abstract:
Novel immunosuppressants, ushikulides A and B, were isolated from the culture broth of Streptomyces sp. IUK-102. Ushikulides A and B both have the same molecular formula, determined as C40H68O10. The structures of both compounds were elucidated to be novel 22-membered macrolides. Both compounds showed immunosuppressive activity for murine splenocyte proliferation in vitro.
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