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Updated: Aug 16, 2026

Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics
Published on: July 31, 2021
The relative and absolute configuration of PF1140
Yuta Fujita1, Hiroki Oguri, Hideaki Oikawa
1Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan. hoik@sci.hokudai.ac.jp
Abstract:
A potentially general approach for elucidating the absolute configuration of N-hydroxypyridone antibiotics has been developed. One member of this family of antibiotics, PF1140, was efficiently purified from a crude fungal extract following allylation of its N-hydroxyl group. Removal of the resultant allyl group permitted regeneration of the N-hydroxyl group as well as conversion into the corresponding pyridone derivative. The stereochemistry of PF1140 including the absolute configuration was established by X-ray crystallographic analysis of the S-2-methoxy-2-(1-naphthyl)propionic ester derivative.
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