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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Does dietary salt increase the risk for progression of kidney disease?
Shiraz I Mishra1, Charlotte Jones-Burton, Jeffrey C Fink
1Division of Nephrology, University of Maryland School of Medicine, 22 S. Greene Street, Room N3W143, Baltimore, MD 21201, USA.
Abstract:
Due to the inconsistent observations and suboptimal quality of the study designs, there is insufficient clinical evidence to suggest that increased salt intake may adversely modify the rate of progression of kidney disease. However, there is experimental evidence to suggest a link between increased salt exposure and kidney tissue injury. Further clinical trials are needed to evaluate the relationship between dietary salt and risk for progression of chronic kidney disease.
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