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Updated: Aug 16, 2026
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
First trimester uterine artery Doppler abnormalities predict subsequent intrauterine growth restriction
Lorraine Dugoff1, Anne M Lynch, Darleen Cioffi-Ragan
1Department of Obstetric and Gynecology, University of Colorado Health Sciences Center, Denver, CO, USA.
Objective:
This study was undertaken to evaluate the association between uterine artery Doppler velocimetry performed between 10 and 14 weeks gestation and intrauterine growth restriction (IUGR).
Study Design:
Uterine artery Doppler velocimetry data were collected on 1067 women enrolled in the FASTER trial at the University of Colorado site. The data were analyzed by using univariate and multivariable logistic regression analysis.
Results:
The uterine artery mean resistance index (RI) for the entire cohort was equal on the right and left sides (0.59 +/- 0.14). Of the 1067 women, 34.2% had unilateral or bilateral diastolic notches, 1 notch was observed in 23.8%, and bilateral notches in 10.4%. Women with a high uterine artery mean RI (> or = 75th percentile) were 5.5 times more likely to have IUGR (95% CI 1.6-18.7). There was no significant relationship between notching and IUGR.
Conclusion:
Elevated first trimester uterine artery mean RI is significantly associated with IUGR.
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