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The pore helix dipole has a minor role in inward rectifier channel function

Franck C Chatelain1, Noga Alagem, Qiang Xu

  • 1Cardiovascular Research Institute, Department of Biochemistry and Biophysics, California Institute for Quantitative Biomedical Research, University of California, San Francisco, Box 2532, San Francisco, California 94143, USA.

Neuron
|September 15, 2005
PubMed
Summary

This study challenges the role of pore helix dipoles in ion channel function. Positively charged mutations in potassium channels confer barium resistance, suggesting electrostatics, not dipoles, drive ion permeation.

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