Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxia-inducible factor as a physiological regulator.

Patrick H Maxwell1

  • 1Hammersmith Campus, Imperial College, London W12 0NN, UK. p.maxwell@imperial.ac.uk

Experimental Physiology
|September 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A framework for the exploration of subcellular compartmentalization of RNA-binding proteins.

Nature communications·2026
Same author

Author Correction: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage.

Nature·2025
Same author

AI education for clinicians.

EClinicalMedicine·2024
Same author

Lifespan Extension by Retrotransposons under Conditions of Mild Stress Requires Genes Involved in tRNA Modifications and Nucleotide Metabolism.

International journal of molecular sciences·2024
Same author

Hypoxia drives HIF2-dependent reversible macrophage cell cycle entry.

Cell reports·2024
Same author

A spatiotemporal atlas of mouse liver homeostasis and regeneration.

Nature genetics·2024

Hypoxia-inducible factor (HIF) is a key regulator of gene transcription in response to low oxygen. This review covers recent findings on HIF activation and its wide-ranging physiological roles.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Physiology

Background:

  • Hypoxia-inducible factor (HIF) is a transcription complex that regulates gene expression in response to oxygen levels.
  • HIF is conserved across species and functions in all mammalian cell types.
  • Understanding HIF is crucial for comprehending cellular adaptation to hypoxia.

Purpose of the Study:

  • To summarize recent molecular insights into HIF activation under reduced oxygen conditions.
  • To explore the extensive physiological roles of HIF.
  • To provide an updated overview of HIF research.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of molecular mechanisms linking oxygen levels to HIF.

Related Experiment Videos

  • Synthesis of findings on HIF's role in various physiological processes.

    • Main Results:

    • Recent advances clarify the molecular events connecting low oxygen to HIF activation.
    • HIF plays a significant role in a broad spectrum of physiological processes.
    • The review highlights the conserved and ancient nature of HIF.

    Conclusions:

    • HIF is a master regulator of cellular response to oxygen.
    • Further research into HIF pathways can reveal new therapeutic targets.
    • HIF's extensive roles underscore its importance in maintaining homeostasis.