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Updated: Jul 15, 2026

Assaying the Kinase Activity of LRRK2 in vitro
Published on: January 18, 2012
A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations
C P Zabetian1, A Samii, A D Mosley
1Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. zabetian@u.washington.edu
Abstract:
Referral-based studies indicate that a mutation (G2019S) in exon 41 of the LRRK2 gene might be a common cause of Parkinson disease (PD). The authors sequenced leucine-rich repeat kinase 2 (LRRK2) exons 31, 35, and 41 in 371 consecutively recruited patients with PD and found mutations in six (1.6%) subjects, including two heterozygous for new putative pathogenic variants (R1441H, IVS31 + 3A-->G). These data confirm the important contribution of LRRK2 to PD susceptibility in a clinic-based population.
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