Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic function after botulinum toxin type A or B: a double-blind, randomized trial.

R Tintner1, R Gross, U F Winzer

  • 1Department of Neurology, Baylor College of Medicine, Houston, TX, USA. rtintner@tmh.tmc.edu

Neurology
|September 15, 2005
PubMed
Summary

Botulinum toxin (BTX) type B caused less saliva production and more constipation than BTX type A in cervical dystonia patients. Other autonomic functions remained similar between treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biliary Enterocytozoon bieneusi infection in a dog under immunomodulatory therapy.

The Journal of small animal practice·2023
Same author

Hyperkinetic movement disorders in congenital disorders of glycosylation.

European journal of neurology·2019
Same author

McLeod syndrome: Five new pedigrees with novel mutations.

Parkinsonism & related disorders·2019
Same author

Association between non-communicable disease multimorbidity and health care utilization in a middle-income country: population-based study.

Public health·2018
Same author

Treatment options for chorea.

Expert review of neurotherapeutics·2017
Same author

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.

Movement disorders : official journal of the Movement Disorder Society·2017

Area of Science:

  • Neurology
  • Pharmacology
  • Autonomic Neuroscience

Background:

  • Cervical dystonia is a neurological movement disorder.
  • Botulinum toxin injections are a primary treatment for cervical dystonia.
  • Autonomic nervous system dysfunction can occur with botulinum toxin treatments.

Purpose of the Study:

  • To compare the autonomic effects of botulinum toxin type A (BTX-A) and botulinum toxin type B (BTX-B).
  • To assess differences in autonomic function following treatment with BTX-A versus BTX-B in cervical dystonia patients.

Main Methods:

  • Double-blind randomized trial comparing BTX-A and BTX-B in cervical dystonia patients.
  • Assessment of autonomic function using physiologic measures and questionnaires.
  • Evaluations conducted at baseline and two weeks post-injection.

Related Experiment Videos

Main Results:

  • Patients receiving BTX-B reported significantly less saliva production (p < 0.01) compared to BTX-A.
  • BTX-B treatment was associated with greater constipation severity (p = 0.037) than BTX-A.
  • No significant differences in other autonomic function tests were observed between the two botulinum toxin types.

Conclusions:

  • Botulinum toxin type B has distinct autonomic side effect profile compared to BTX-A in cervical dystonia.
  • Reduced salivation and increased constipation are potential adverse effects specific to BTX-B treatment.
  • Further research into managing these specific autonomic effects is warranted.