Related Experiment Video

Updated: Aug 16, 2026

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
09:05

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Published on: May 4, 2015

Histopathological changes of biopsied myocardium in Shoshin beriberi

Hiroaki Kawano1, Tomayoshi Hayashi, Yuji Koide

  • 1Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University, Nagasaki 852-8501, Japan.

International Heart Journal
|September 15, 2005
PubMed

Insights

Shoshin beriberi, a severe form of cardiac beriberi caused by thiamine deficiency, presents persistent myocardial fibrosis and fiber size variation even after treatment. These histopathological changes are observed in both alcoholic and nonalcoholic cases.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Pathology

Background:

  • Cardiovascular beriberi results from thiamine deficiency, often linked to alcoholism or poor diet.
  • Shoshin beriberi represents a critical, rapidly progressing form of cardiac beriberi.

Observation:

  • This study examined myocardial tissue from two Shoshin beriberi patients post-thiamine treatment.
  • One patient had nonalcoholic beriberi, the other had alcoholic beriberi.

Findings:

  • Persistent interstitial fibrosis was noted in myocardial samples.
  • Variations in myocardial fiber size were a consistent histopathological finding.

Implications:

  • These persistent changes suggest long-term cardiac impact of Shoshin beriberi.
  • Understanding these features is crucial for managing patients with thiamine deficiency-related heart conditions.

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...