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Related Experiment Videos

Biphasic versus sequential pulse defibrillation: a direct comparison in pigs.

D L Jones1, G J Klein, G K Wood

  • 1Department of Medicine, University of Western Ontario, London, Canada.

American Heart Journal
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

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Sequential pulse defibrillation is more effective than biphasic shocks, requiring less energy for successful defibrillation in pigs. This study highlights sequential pulse as a superior current delivery system.

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Biphasic and sequential pulse defibrillation shocks demonstrate superiority over monophasic shocks.
  • Limited data exists comparing biphasic and sequential pulse waveforms under controlled conditions.

Purpose of the Study:

  • To directly compare the defibrillation efficacy of biphasic and sequential pulse shocks.
  • To evaluate these waveforms while maintaining constant pulse characteristics, subject, and electrode surface area.

Main Methods:

  • Pigs (18-28 kg) were randomized in a cross-over design for defibrillation threshold determination.
  • Triplicate determinations used biphasic and sequential pulse shocks with large (26 cm2) and small (13 cm2) epicardial electrodes.
  • Delivered voltage, current, and energy were recorded.

Related Experiment Videos

Main Results:

  • Sequential pulse shocks required significantly lower delivered energy than biphasic shocks for both electrode sizes.
  • All pigs were defibrillated with sequential pulse shocks (<800 V), while six could not be defibrillated with biphasic shocks (900 V).
  • Sequential pulse defibrillation demonstrated superior current delivery compared to biphasic shocks.

Conclusions:

  • Sequential pulse defibrillation using three electrodes is a more effective current delivery system than biphasic shocks with two electrodes.
  • This superiority is evident when subject, waveform characteristics, and total electrode surface area are constant.
  • Sequential pulse defibrillation represents an advancement in defibrillation technology.