Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cortical progenitor cells in the developing human telencephalon.

Brian Howard1, Yanhui Chen, Nada Zecevic

  • 1Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3401, USA.

Glia
|September 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated deep learning-based retinoschisis and detachment volume measurement in pathological myopia with posterior scleral contraction.

The British journal of ophthalmology·2026
Same author

Integrated physiological and transcriptomic measurements reveal changes in the accumulation and partitioning of storage reserves after prevention of pollination in maize.

BMC plant biology·2026
Same author

Self-Adaptive Solar-Thermal System With Moss-Like Surface for Efficient Energy Utilization.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Phase selection behavior of nanosized GaIn liquid alloys governed by mixing enthalpy.

Nanoscale·2026
Same author

Identifying the significant drivers of containerized freight rates: From the perspective of dynamic multiscale dependence.

PloS one·2026
Same author

Integrated bioinformatics reveals tubulointerstitial immune microenvironment signatures and machine learning-driven prognostication of clinical treatment response in lupus nephritis.

Autoimmunity·2026
Same journal

A Super-Resolution Approach for Astrocyte-Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling.

Glia·2026
Same journal

Blocking CK2α-Bclaf1 Preserves Oligodendrocytes After Neonatal Hypoxic Injury.

Glia·2026
Same journal

Molecular Characteristics and Differentiation Control Mechanisms of Bergmann Glia-Like Progenitors in the Postnatal Mouse Cerebellum.

Glia·2026
Same journal

Alzheimer's Protection by PLCγ2 Compacts Plaques, Redistributes Microglia, and Protects Synapses in App<sup>NL</sup> <sup>-G-F</sup> Mice.

Glia·2026
Same journal

Single-Nucleus Multiomic Analysis Reveals Immune-Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV-Associated Neurocognitive Disorders.

Glia·2026
Same journal

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation.

Glia·2026
See all related articles

Radial glial (RG) cells are key neural progenitors. This study maps their molecular and spatial characteristics in the developing human brain, revealing progenitor diversity that may explain cortical complexity.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Radial glial (RG) cells are crucial neural progenitors, but their molecular and spatiotemporal profiles in the human fetal brain remain incompletely understood.
  • Investigating these characteristics is vital for comprehending human brain development and complexity.

Purpose of the Study:

  • To characterize the molecular and spatiotemporal distribution of radial glial (RG) cells and other neuronal progenitors in the early human fetal brain.
  • To understand the diversity of neural progenitor cells during human cortical development.

Main Methods:

  • Utilized glial and neuronal-specific antibodies for antigen profiling and distribution analysis.
  • Examined cell proliferation and marker expression in the ventricular zone (VZ) and developing cerebral cortex.

Related Experiment Videos

  • Quantified RG subtypes using glial markers in vitro.

    • Main Results:

    • Proliferating RG (4A4+) cells exhibited distinct caudorostral and ventrodorsal gradients in early embryonic stages (4.5-5.5 gestational weeks).
    • Other dividing cells expressed neuronal markers (SMI-31) throughout the early central nervous system (CNS).
    • At cortical neurogenesis onset (6 gw), diverse progenitor populations, including RG and neuronal progenitors, were found in close proximity.
    • By midgestation (17-24 gw), RG divisions were less frequent but distributed across the cerebral cortex, with identified RG subtypes.

    Conclusions:

    • The human brain exhibits a diverse array of cortical progenitors, including various RG subtypes.
    • This progenitor cell diversity likely contributes to the intricate structure and complexity of the human cerebral cortex.