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Updated: Aug 8, 2026

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
Published on: January 6, 2016
Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation
Irene Faenza1, Anna Maria Billi, Matilde Yung Follo
1Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Italy.
Abstract:
The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment.
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