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Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis

Marija Djukic1, Tobias Böttcher, Andreas Wellmer

  • 1Department of Neurology, University of Göttingen, Göttingen, Germany.

Neurocritical Care
|September 15, 2005
PubMed

Insights

Moxifloxacin did not reduce mortality in a mouse meningitis model compared to ceftriaxone. This study investigated moxifloxacin

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Rifampin, a protein synthesis inhibitor, demonstrated reduced mortality in a mouse meningitis model.
  • Cephalosporins, used as standard therapy, exhibit bacteriolytic properties.
  • Moxifloxacin, a fluoroquinolone, exhibits less rapid bacteriolysis compared to cephalosporins.

Purpose of the Study:

  • To evaluate if moxifloxacin can similarly reduce mortality in a mouse model of Streptococcus pneumoniae meningitis.
  • To compare the efficacy of moxifloxacin versus ceftriaxone in reducing mortality.

Main Methods:

  • Mice were infected with Streptococcus pneumoniae via deep intracerebral injection.
  • Mice received subcutaneous treatment of either moxifloxacin (200 mg/kg) or ceftriaxone every 8 hours for 5 days.
  • Mortality was observed for an additional 8 days post-treatment.

Main Results:

  • Overall mortality was 35 in the moxifloxacin group and 29 in the ceftriaxone group.
  • No statistically significant difference in mortality was observed between the two treatment groups (p = 0.29).
  • Kaplan-Meier survival analysis showed no significant difference (p = 0.32).

Conclusions:

  • Moxifloxacin failed to demonstrate a reduction in mortality compared to ceftriaxone in this mouse model of meningitis.
  • The findings suggest that moxifloxacin may not offer a survival advantage over cephalosporins in this specific infection model.

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