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Updated: Aug 16, 2026

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Published on: November 18, 2018
Platypnea-orthodeoxia associated with a fenestrated atrial septal aneurysm: case report
William J van Gaal1, Majo Joseph, Elizabeth Jones
1Department of Cardiology, John Radcliffe Hospital, Headington, Oxon, OX3 9DU, UK. william@vangaal.org
Background:
Platypnea-orthodeoxia describes the condition of combined dyspnea and hypoxia respectively, whilst in the upright position, which improves in the recumbent position.
Case Report:
We present a case of platypnea-orthodeoxia due to a fenestrated atrial septal defect associated with an atrial septal aneurysm. Due to the fenestrated nature of the atrial septal defect, surgical rather than percutaneous correction was performed.
Conclusion:
A high index of suspicion is required to diagnose the syndrome of platypnea-orthodeoxia. Careful echocardiographic evaluation is required to identify the syndrome, and to determine suitability for percutaneous repair.
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