Related Experiment Video

Updated: Jul 31, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Targeting angiogenesis with vascular endothelial growth factor receptor small-molecule inhibitors: novel agents with

Heather A Wakelee1, Joan H Schiller

  • 1Oncology Division, Stanford University School of Medicine, CA, USA.

Clinical Lung Cancer
|September 15, 2005
PubMed

Insights

New targeted therapies, specifically tyrosine kinase inhibitors blocking vascular endothelial growth factor (VEGF) receptors, show promise for lung cancer treatment. These agents offer a novel approach beyond traditional chemotherapy.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Lung cancer treatment faces challenges with chemotherapy efficacy reaching a plateau.
  • Targeted therapies, including those against the epidermal growth factor receptor and antiangiogenesis agents, represent promising new avenues.

Purpose of the Study:

  • To review the development of tyrosine kinase inhibitors targeting vascular endothelial growth factor (VEGF) receptors for lung cancer.
  • To present available Phase I, II, and III data for these novel agents.

Main Methods:

  • Focus on tyrosine kinase inhibitors (TKIs) of VEGF receptors.
  • Review of clinical trial data (Phase I, II, and III) for specific TKIs.

Main Results:

  • Several TKIs targeting VEGF receptors are in early development.
  • Data from Phase I trials are presented, with Phase II/III data included where available.

Conclusions:

  • Tyrosine kinase inhibitors of VEGF receptors are emerging as a potential new class of drugs for lung cancer.
  • Further clinical development is necessary to establish their role in lung cancer therapy.

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