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Updated: Aug 16, 2026
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
[Effect of PC-1 gene expression on migration ability of prostate cancer cells]
Hui Zhang1, Li-Chuan Wan, Jian Wang
1Laboratory of Molecular Oncology, Institute of Biotechnology, Academy of Military Medical Science, Beijing, P.R. China.
Background & Objective:
PC-1 gene is highly expressed in C4-2 cell line, an androgen-independent and aggressive prostate cancer cell line, but lowly expressed in LNCaP cell line, an androgen-dependent prostate cancer cell line. This study was to assess the contribution of PC-1 gene to migration of prostate cancer cells.
Methods:
LNCaP cell line with stable expression of PC-1 gene and C4-2 cell line with antisense nucleotide-down-regulated PC-1 were established. The migration abilities of LNCaP and C4-2 cells were tested using an in vitro transwell invasion assay.
Results:
Migration cell count of LNCaP cells with up-regulation of PC-1 gene was similar to that of control LNCaP cells(P>0.05); migration cell count was significantly lower in C4-2 cells with down-regulation of endogenous PC-1 gene than in control C4-2 cells (P<0.05).
Conclusion:
PC-1 may be involved in the invasion of prostate cancer cells.
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