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Updated: Aug 13, 2026

A Preclinical Murine Model of Hepatic Metastases
Published on: September 27, 2014
[Research advancement on heparanase in tumor metastasis]
1Department of Gastroenterology, Southwest Hospital, The Third Military Medical University, Chongqing, P.R. China.
Abstract:
Heparanase is the only mammalian heparan sulfate-degrading enzymes; it could cleave heparan sulfate (HS) which links to heparan sulfate proteoglycans (HSPGs). In this review, the heparanase's structure, function, molecular properties, gene location, nucleotide sequence, its effects on tumor angiogenesis, its expression in normal tissue, tumor tissue and metastatic tissue, and its correlation to tumor metastasis were described; recent progress in searching for novel antitumor drugs through screening for inhibitor of heparanase was summarized.
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