Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimation of sex-age specific clinical reference ranges by nonlinear optimization method.

Takeo Shibata1, Yoichi Ogushi, Teppei Ogawa

  • 1Department of Medical Education and Informatics, School of Medicine, Tokai University, Japan. tshibata@is.icc.u-tokai.ac.jp

Studies in Health Technology and Informatics
|September 15, 2005
PubMed
Summary

Established clinical reference ranges lack sex and age specificity. This study analyzed 700,000 health records, revealing significant sex-age differences in 24 health items, necessitating updated diagnostic standards.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between red blood cell transfusion volume and infection risk: a dose-response analysis of a nationwide trauma registry.

Critical care (London, England)·2026
Same author

Clonal Evolution of Endometriosis to Peritoneal Endometrioid Carcinoma via <i>PTEN</i> Biallelic Inactivation: A Case Report With Integrated Genomic and Pathological Profiling.

JCO precision oncology·2026
Same author

Identification and structural characterization of soluble dectin-1 with β-glucan-binding activity in THP-1 cell culture supernatant.

Immunobiology·2026
Same author

Dietary β-1,3/1,6-Glucan from Baker's Yeast Supports Upper Respiratory Mucosal Immune Health in Healthy Adults: Evidence from a Randomized, Double-Blind, Placebo-Controlled Trial.

Nutrients·2026
Same author

A transparent osmotic wound dressing ATKPAD promotes the healing process and regulates hypoxia-dependent inflammatory responses.

Scientific reports·2026
Same author

Leukocytoclastic vasculitis of the extremities secondary to pancreatic cancer and Escherichia coli abscess; An unusual case of distinct etiologies in the same patient.

Fukushima journal of medical science·2026

Area of Science:

  • Clinical Chemistry
  • Biostatistics
  • Public Health

Background:

  • Current clinical reference ranges often overlook crucial sex and age-related variations.
  • This oversight can lead to misdiagnosis and inappropriate medical treatment.

Purpose of the Study:

  • To establish sex-age specific clinical reference ranges using a large health examination dataset.
  • To evaluate the impact of sex-age specific ranges on diagnostic accuracy.

Main Methods:

  • Analysis of approximately 700,000 health examination records covering 24 clinical items.
  • Application of a novel nonlinear optimization method aligned with NCCLS guidelines.

Main Results:

  • All 24 analyzed health items demonstrated significant sex-age specific reference range differences.

Related Experiment Videos

  • Hepatic and diabetic functions, blood pressure, and total cholesterol showed particularly notable variations across different demographic groups.

    • Conclusions:

    • Existing reference ranges may lead to under-diagnosis in some individuals and over-treatment in others.
    • Implementing sex-age specific reference ranges is critical for accurate clinical assessment and personalized medicine.