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Updated: Aug 16, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Pharmacotherapy of epileptic seizures in glioma patients: who, when, why and how long?
Wolfgang Wick1, Oliver Menn, Christoph Meisner
1Abteilung für Allgemeine Neurologie, Hertie-Institut für Klinische Hirnforschung, Zentrum für Neurologie, Universitatsklinikum Tübingen, Germany. wolfgang.wick@uni-tuebingen.de
Background:
The risk for patients with primary brain tumors of experiencing an epileptic seizure at least once in the course of disease probably exceeds 50%, depending on tumor location and tumor type. Several aspects regarding the role of anticonvulsants in the treatment of brain tumor patients have remained controversial.
Patients And Methods:
We reviewed the seizure history in 107 patients undergoing a surgical procedure for glioma at our institution.
Results:
The overall seizure incidence was 68%. Pre-operative seizures did not predict the occurrence of post-operative seizures. After surgery, postoperative chemo- or radiotherapy and anticonvulsive therapy one third of patients was seizure-free whereas one third showed frequent seizures despite this treatment. Seizure frequency increased regardless of anticonvulsive treatment with progressive or recurrent tumor growth.
Conclusions:
Based on a literature review and our institutional experience, we delineate some recommendations for the management of seizures in patients with brain tumors.
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