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Sudden death in childhood due to varicella pneumonia: a forensic case report with clinical implications
H Pfeiffer1, K Varchmin-Schultheiss, B Brinkmann
1Institute of Legal Medicine, Röngenstrasse 23, 48149, Münster, Germany. pfeiffh@uni-muenster.de
Insights
Varicella (chickenpox) can cause fatal pneumonia, even in healthy children. Early varicella vaccination is crucial for preventing severe complications and deaths from this common childhood illness.
Area of Science:
- Pathology
- Virology
- Pediatrics
Background:
- Varicella-zoster virus (VZV) causes varicella (chickenpox), a common childhood infection.
- Lethal complications from VZV are rare, but can occur.
Observation:
- A case study of an 18-month-old girl with sudden unexpected death.
- The child was previously healthy and diagnosed with varicella.
Findings:
- Histological examination revealed varicella-induced pneumonia.
- Lung tissue showed hemorrhagic and necrotic nodules, fibrin, inflammatory cells, and giant cells.
Implications:
- Varicella pneumonia can be a fatal complication of VZV infection.
- Vaccination against varicella is essential for preventing severe outcomes and deaths in children.
- Pediatricians should adhere to varicella vaccination guidelines to prevent such tragedies.
Abstract:
Varicella (chickenpox) is one of the most frequent highly infectious diseases in childhood. It is caused by varicella-zoster virus. Lethal complications are rare. Focused on histological findings, we present a case of a sudden unexpected death of an otherwise healthy 18-month-old girl due to varicella-induced pneumonia. The histological and immunohistochemical investigations of the lung tissue revealed typical findings of a varicella pneumonia: haemorrhagic and necrotic nodules, intra-alveolar fibrin, numerous neutrophilic granulocytes, lymphocytes, plasmacells, macrophages, multinucleated giant cells and hyaline membranes. Varicella-related deaths are preventable by vaccine. To prevent complications and lethal outcome of varicella as reported here, the recommendations concerning vaccination against varicella must be taken into account in paediatric practice.
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The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.