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Updated: Aug 16, 2026
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
[Effects of xianggui pill on cytokine in endometriosis model rat]
Yong-Jiu Tang1, Yi Chen, He-Yong Yu
1Women's Hospital, Zhejiang University, School of Medicine, Hangzhou 310006, China. yjk.hf@mail.hz.zj.cn
Objective:
To study the adjustment of Xianggui pill on the cytokine of endometriosis model rat, and investigate the mechanism of Xianggui pill on the treatment of endometriosis.
Method:
To set up endometriosis model by rat self-endometria transplantation, drench sodium chloride, Xianggui pill elixation or Danazol after grouping, and to detect the contents of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) by ELISA.
Result:
The contents of IL-8, TNF-alpha in the peripheral blood and peritoneal fluid of model group were higher than that of the blank group; The quality of allotopia growth intima tissue, the quantity of macrophage in peritoneal fluid and the contents of IL-8, TNF-alpha in the Xianggui pill group and Danazol group were all lower than those of the model group; but there was no significant difference of each target between the Xianggui pill group and Danazol group.
Conclusion:
Xianggui pill can restrain significantly the growth of allotopia intima tissue, and has apparently adjustment to the cytokine.
