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Updated: Aug 16, 2026

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Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
Published on: October 2, 2017
The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. III. Structure determination
Yoshihiro Ohtsu1, Seiji Yoshimura, Takayoshi Kinoshita
1Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd.
The Journal of Antibiotics
|September 16, 2005
Abstract:
A novel gluconeogenesis inhibitor, FR225654 was isolated from the culture broth of Phoma sp. No. 00144. Spectroscopic analysis concluded that FR225654 has a highly oxygenated trans-decalin ring and beta-keto-enol in its main part, and has a characteristic side chain possessing a conjugated carboxylic acid and tri-substituted olefin.

