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[Atherosclerosis imaging to assess plaque progression].

Paolo Raggi1, Antonio Bellasi

  • 1Section of Cardiology, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL48, New Orleans, LA 70112-2699, USA. praggi@tulane.edu

Italian Heart Journal. Supplement : Official Journal of the Italian Federation of Cardiology
|September 16, 2005
PubMed
Summary

Tracking atherosclerotic plaque progression aids cardiovascular risk prediction. Noninvasive imaging offers potential for earlier detection and efficient clinical trials, reducing healthcare costs.

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Preventive Medicine

Background:

  • Cardiovascular disease is a leading cause of death globally.
  • Monitoring atherosclerotic plaque progression is crucial for predicting individual patient risk.
  • Quantitative coronary angiography has been used to assess disease progression and outcomes.

Purpose of the Study:

  • To explore the role of noninvasive imaging in detecting preclinical atherosclerotic plaque.
  • To evaluate the effectiveness of preventive therapies using sequential imaging.
  • To assess the potential of imaging tools in clinical trials for atherosclerosis.

Main Methods:

  • Review of quantitative coronary angiography for plaque assessment.
  • Focus on development of noninvasive imaging modalities.

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  • Utilizing sequential imaging for evaluating therapeutic interventions.

    • Main Results:

    • Quantitative coronary angiography demonstrated plaque regression is linked to reduced adverse cardiovascular events.
    • Emerging noninvasive techniques aim for early plaque detection.
    • Noninvasive imaging can serve as intermediate endpoints in clinical trials.

    Conclusions:

    • Noninvasive imaging of atherosclerotic plaque is a promising area for cardiovascular risk assessment.
    • These techniques may streamline clinical trials for atherosclerosis treatments.
    • Successful implementation could lead to significant cost savings in healthcare.