RNAi mechanisms in Caenorhabditis elegans
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Updated: Aug 15, 2026

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
Published on: February 13, 2012
1Center for Cancer Research, MIT, E17-526, 40 Ames Street, Cambridge, MA 02139, USA. agrishok@mit.edu
Abstract:
RNA interference (RNAi) is a form of gene silencing induced by double stranded RNA (dsRNA) that is processed into short interfering RNAs (siRNAs). RNAi can induce both post-transcriptional and transcriptional gene silencing. In Caenorhabditis elegans, there are several distinct pathways where post-transcriptional or/and transcriptional RNAi mechanisms are involved. RNAi in C. elegans is also systemic and heritable. This review will discuss RNAi related pathways, features of RNAi in C. elegans and possibilities of endogenous gene regulation by RNAi.
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