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Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversy

R Zbinden1, S Zbinden, M Billinger

  • 1Department of Cardiology, University Hospital Bern, Bern, Switzerland.

Heart (British Cardiac Society)
|September 16, 2005
PubMed

Insights

Diabetes does not impact coronary collateral flow in patients with stable coronary artery disease. Accurate collateral flow index (CFI) measurements show no significant difference between diabetic and non-diabetic individuals.

Area of Science:

  • Cardiology
  • Diabetology
  • Vascular Physiology

Background:

  • Diabetes mellitus is a significant risk factor for coronary artery disease.
  • The impact of diabetes on coronary collateral circulation, crucial for myocardial perfusion during ischemia, remains incompletely understood.

Purpose of the Study:

  • To quantitatively assess the influence of diabetes mellitus on coronary collateral flow.
  • To compare collateral flow index (CFI) in diabetic versus matched non-diabetic patients with coronary artery disease.

Main Methods:

  • A cohort of 200 patients (100 diabetic, 100 non-diabetic) with coronary artery disease was studied.
  • Coronary collateral flow was measured using pressure and/or Doppler guidewires to calculate the collateral flow index (CFI).
  • Diabetic and non-diabetic groups were meticulously matched for clinical, hemodynamic, and angiographic characteristics.

Main Results:

  • No significant difference in quantitatively measured CFI was observed between diabetic and non-diabetic patients (0.21 vs. 0.19, p > 0.05).
  • CFI also did not differ significantly when comparing angiographically normal vessels or chronic total coronary occlusions between the groups.
  • A trend towards fewer diabetic patients experiencing angina during vessel occlusion was noted, though not statistically significant.

Conclusions:

  • Quantitatively measured coronary collateral flow, assessed by CFI, is not significantly different between diabetic and non-diabetic patients with stable coronary artery disease.
  • These findings suggest that diabetes does not impair the development or function of coronary collateral circulation in this patient population.
Abstract

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