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Pulmonary inflammatory pseudotumor (inflammatory myofibroblastic tumor): CT features with pathologic correlation
Tae Sung Kim1, Joungho Han, Gou Young Kim
1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Journal of Computer Assisted Tomography
|September 16, 2005
Summary
This study analyzed CT scans of pulmonary inflammatory myofibroblastic tumors. Findings reveal these tumors are closely related to the airway, often appearing as endobronchial or peripheral nodules.
Area of Science:
- Pulmonary Medicine
- Radiology
- Pathology
Background:
- Pulmonary inflammatory myofibroblastic tumors (IMT) are rare neoplasms.
- Accurate diagnosis relies on correlating imaging with histopathology.
Purpose of the Study:
- To evaluate the computed tomography (CT) imaging characteristics of pulmonary IMT.
- To correlate CT findings with pathological examination in a cohort of patients.
Main Methods:
- Retrospective review of CT scans and surgical pathology reports for 10 patients with pulmonary IMT.
- Analysis of tumor location, size, margins, and contrast enhancement on CT.
- Histopathological correlation of imaging findings.
Main Results:
- CT revealed diverse appearances: polypoid endotracheal/endobronchial nodules (n=5), central parenchymal masses (n=2), and peripheral pulmonary nodules (n=3).
- All tumors exhibited well-defined, round to ovoid shapes (13-52 mm diameter) with variable contrast enhancement.
- Pathology confirmed endobronchial or peribronchiolar locations, often involving airways.
Conclusions:
- Pulmonary IMT frequently demonstrate airway-centric patterns on CT.
- CT features, particularly endobronchial or peripheral nodular/mass lesions, suggest a close relationship with the airway in IMT.
- Integration of CT imaging and histopathology is crucial for diagnosing pulmonary IMT.