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[Bickerstaff's encephalitis].

J García-García1, S Calleja, J M Fernández

  • 1Servicio de Neurología II, Hospital Universitario Central de Asturias, Oviedo. jggpillarno@hotmail.com

Neurologia (Barcelona, Spain)
|September 16, 2005
PubMed
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Bickerstaff encephalitis (BBE) is a rare neurological disorder. Prompt treatment with intravenous immunoglobulins led to full recovery in a patient with BBE, suggesting its efficacy.

Area of Science:

  • Neurology
  • Neuroimmunology

Background:

  • Bickerstaff encephalitis (BBE) is a rare neurological disorder.
  • It shares features with Miller Fisher syndrome and Guillain Barré syndrome.
  • Understanding BBE's autoimmune basis is crucial for effective treatment.

Observation:

  • A 44-year-old male presented with ophthalmoplegia, ataxia, and consciousness disturbances post-respiratory infection.
  • Brainstem lesions were identified via MRI, with CSF showing albuminocytologic dissociation and oligoclonal bands.
  • Peripheral nervous system involvement (absent reflexes) was noted.

Findings:

  • Diagnosis of BBE with overlapping peripheral nervous system features.
  • Presence of CSF oligoclonal bands correlated with disease activity, decreasing upon recovery.

Related Experiment Videos

  • Complete clinical recovery and MRI lesion resolution after high-dose intravenous immunoglobulin (IVIg) therapy.

    • Implications:

    • The findings support an autoimmune pathogenesis in BBE, indicated by CSF oligoclonal bands.
    • IVIg therapy is a potential treatment option for Bickerstaff encephalitis.
    • Early diagnosis and intervention with IVIg may improve patient outcomes in BBE.